Congenital diaphragmatic hernia (CDH) should be diagnosed in the prenatal period and prompt referral to a tertiary referral center for imaging, genetic testing, and multidisciplinary counseling. Individual prediction of prognosis is based on the absence of additional anomalies, lung size, and liver herniation. In severe cases, a prenatal endotracheal balloon procedure is currently being offered at specialized centers. Fetal intervention is now also offered to milder cases within a trial, hypothesizing that this may reduce the occurrence of bronchopulmonary dysplasia in survivors. Postnatal management has been standardized by European high-volume centers for the purpose of this and other trials.

Additional Metadata
Keywords Congenital diaphragmatic hernia, Fetal tracheal occlusion, Neonatal management, Prediction of outcome, Prenatal diagnosis
Persistent URL dx.doi.org/10.1016/j.clp.2009.03.004, hdl.handle.net/1765/26987
Journal Clinics in Perinatology
Citation
Deprest, J.A, Gratacos, E, Nicolaides, K, Done, E, van Mieghem, T, Gucciardo, L, … Tibboel, D. (2009). Changing Perspectives on the Perinatal Management of Isolated Congenital Diaphragmatic Hernia in Europe. Clinics in Perinatology (Vol. 36, pp. 329–347). doi:10.1016/j.clp.2009.03.004