We present two prostate cancer patients, including one with a castration-resistant cancer whose rising serum prostate-specific antigen (PSA) levels showed a remarkable drop after a reactivated varicella-zoster virus infection treated with valaciclovir. In one patient, we found a temporary decrease in serum PSA lasting for at least 4 mo. In the patient with castration-resistant prostate cancer, serum PSA decreased to <0.01 μg/l and has remained undetectable since.

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doi.org/10.1016/j.eururo.2009.02.025, hdl.handle.net/1765/27006
European Urology : Official Journal of the European Association of Urology
Erasmus MC: University Medical Center Rotterdam

Jurhill, R., van der Veen, H., Leenders, G., & Verhagen, P. (2009). Reduction of Serum Prostate-Specific Antigen Levels following Varicella-Zoster Infection and Valaciclovir Treatment in Prostate Cancer. European Urology : Official Journal of the European Association of Urology, 56(2), 392–394. doi:10.1016/j.eururo.2009.02.025