The spectrum of phenotypes caused by variants in the CFH gene
Molecular Immunology , Volume 46 - Issue 8-9 p. 1573- 1594
Complement factor H (CFH) is a complement inhibitor, which is present as a soluble protein and attached to cell surfaces throughout the human body. As such, CFH is a key player in complement homeostasis, inhibiting excessive activation of the complement cascade, with an emphasis on the alternative pathway. The significance of CFH is demonstrated by the broad range of phenotypes associated with specific CFH gene variants. This phenotypic spectrum includes renal phenotypes, such as membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome, as well as ocular phenotypes, such as basal laminar drusen and age-related macular degeneration. In addition, several overlapping phenotypes have been described in association with CFH gene variants. The phenotypic outcome of these CFH variants depends on their differential impact on plasma- and surface-bound CFH function. Consequently, distinct genotype-phenotype correlations may be observed.
|Age-related macular degeneration, Atypical hemolytic uremic syndrome, Basal laminar drusen, CFH, Complement, Drusen, Genotype-phenotype correlation, Membranoproliferative glomerulonephritis|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Boon, C.J.F, van de Kar, N.C, Klevering, B.J, Keunen, J.E.E, Cremers, F.P.M, Klaver, C.C.W, … Hollander, A.I. (2009). The spectrum of phenotypes caused by variants in the CFH gene. Molecular Immunology (Vol. 46, pp. 1573–1594). doi:10.1016/j.molimm.2009.02.013