Timing and plasticity in the cerebellum: focus on the granular layer
Trends in Neurosciences , Volume 32 - Issue 1 p. 30- 40
Two of the most striking properties of the cerebellum are its control in timing of motor operations and its ability to adapt behavior to new sensorimotor associations. Here, we propose a 'time-window matching' hypothesis for granular layer processing. Our hypothesis states that mossy fiber inputs to the granular layer are transformed into well-timed spike bursts by intrinsic granule cell processing, that feedforward Golgi cell inhibition sets a limit to the duration of such bursts and that these activities are spread over particular fields in the granular layer so as to generate ongoing time-windows for proper control of interacting motor domains. The role of synaptic plasticity would be that of fine-tuning pre-wired circuits favoring activation of specific granule cell groups in relation to particular time windows. This concept has wide implications for processing in the olivo-cerebellar system as a whole.
|Trends in Neurosciences|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
D'Angelo, E, & de Zeeuw, C.I. (2009). Timing and plasticity in the cerebellum: focus on the granular layer. Trends in Neurosciences (Vol. 32, pp. 30–40). doi:10.1016/j.tins.2008.09.007