Complexity of the association between psoriasis and comorbidities
The Journal of Investigative Dermatology , Volume 129 - Issue 7 p. 1601- 1603
Multiple observational studies have recently demonstrated associations between psoriasis and several comorbidities-especially metabolic syndrome and cardiovascular disease, and now osteoporosis. It has been hypothesized that elevated levels of tumor necrosis factor-α are a biological explanation for the observed associations. In this commentary, we discuss the complexity of associations between psoriasis and comorbidities, possible residual confounding, the limitations of observational studies in proving causality, absolute versus relative risk differences, and the clinical relevance and possible clinical impact of "upgrading" psoriasis to a systemic disease.
|The Journal of Investigative Dermatology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Nijsten, T.E.C, & Wakkee, M. (2009). Complexity of the association between psoriasis and comorbidities. The Journal of Investigative Dermatology (Vol. 129, pp. 1601–1603). doi:10.1038/jid.2009.55