Although it is tempting to speculate that the (pro)renin receptor is the missing link providing a role for prorenin in tissue angiotensin generation, the discrepant results with handle region peptide and the lack of clinical studies with (pro)renin receptor blockers do not yet firmly support such a role.

(Pro)renin receptor, Prorenin, Renin inhibitor, Renin-angiotensin system, Transforming growth factor β,
Current Opinion in Nephrology & Hypertension
Erasmus MC: University Medical Center Rotterdam

Danser, A.H.J. (2009). (Pro)renin receptors: are they biologically relevant?. Current Opinion in Nephrology & Hypertension (Vol. 18, pp. 74–78). doi:10.1097/MNH.0b013e3283196aaf