Actin in dendritic spines: Connecting dynamics to function
The Journal of Cell Biology , Volume 189 - Issue 4 p. 619- 629
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses and are major sites of information processing and storage in the brain. Changes in the shape and size of dendritic spines are correlated with the strength of excitatory synaptic connections and heavily depend on remodeling of its underlying actin cytoskeleton. Emerging evidence suggests that most signaling pathways linking synaptic activity to spine morphology influence local actin dynamics. Therefore, specific mechanisms of actin regulation are integral to the formation, maturation, and plasticity of dendritic spines and to learning and memory.
|The Journal of Cell Biology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Hotulainen, P, & Hoogenraad, C.C. (2010). Actin in dendritic spines: Connecting dynamics to function. The Journal of Cell Biology (Vol. 189, pp. 619–629). doi:10.1083/jcb.201003008