Origin and functional specializations of DC subsets in the lung
European Journal of Immunology , Volume 40 - Issue 8 p. 2112- 2118
Lung DC bridge innate and adaptive immunity, and depending on the context, induce Th1, Th2 or Th17 response, to optimally clear infections. Conversely, lung DC can also prevent overt and harmful immune responses to harmless inhaled antigens via induction of Treg or via induction of neutralizing mucosal IgA antibodies. Here, we propose that these functions are not the result of a single population of DC, and instead, subsets of DC perform specialized functions.
|Asthma, DC, Influenza, Lung, T-cell polarization|
|European Journal of Immunology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Plantinga, M, Hammad, H, & Lambrecht, B.N.M. (2010). Origin and functional specializations of DC subsets in the lung. European Journal of Immunology (Vol. 40, pp. 2112–2118). doi:10.1002/eji.201040562