Orbital fibroblasts play a key role in the pathogenesis of Graves' ophthalmopathy (GO). We discuss some major aspects by which orbital fibroblasts contribute to GO and the important role of PDGF-BB herein. Finally, we propose the orbital fibroblast, and especially the PDGF system acting on orbital fibroblasts, as an important therapeutic target in GO.

Graves' Ophthalmopathy, Orbital fibroblast, PDGF, Pathogenesis, Therapy
dx.doi.org/10.3109/01676831003668443, hdl.handle.net/1765/27698
Erasmus MC: University Medical Center Rotterdam

van Steensel, L, & Dik, W.A. (2010). The orbital fibroblast: A key player and target for therapy in Graves' ophthalmopathy. Orbit (Vol. 29, pp. 202–206). doi:10.3109/01676831003668443