We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions.

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doi.org/10.1016/j.leukres.2009.10.026, hdl.handle.net/1765/27795
Leukemia Research: clinical and laboratory studies
Erasmus MC: University Medical Center Rotterdam

Corthals, S.L, Jongen-Lavrencic, M, de Knegt, Y, Peeters, J.K, Beverloo, H.B, Lokhorst, H.M, & Sonneveld, P. (2010). Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma. Leukemia Research: clinical and laboratory studies, 34(5), 677–681. doi:10.1016/j.leukres.2009.10.026