2010-11-01
Genetic variation in homocysteine metabolism, cognition, and white matter lesions
Publication
Publication
Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology , Volume 31 - Issue 11 p. 2020- 2022
Several studies have shown an association between homocysteine concentration and cognitive performance or cerebral white matter lesions. However, variations in genes encoding for enzymes and other proteins that play a role in homocysteine metabolism have hardly been evaluated in relation to these outcome measures. In the population-based Rotterdam Scan Study, we examined the association of seven polymorphisms of genes involved in homocysteine metabolism (MTHFR 677C>T, MTHFR 1298A>C, RFC 80G>A, TC 776C > G, MTR 2756A > G, MTRR 66A > G, and CBS 844ins68) with plasma total homocysteine, cognitive performance, and cerebral white matter lesions among 1011 non-demented elderly participants. Of all the studied polymorphisms, only MTHFR 677C > T was associated with homocysteine concentration. No significant relationship was observed for any of the polymorphisms with cognitive performance or severity of cerebral white matter lesions.
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| doi.org/10.1016/j.neurobiolaging.2008.10.004, hdl.handle.net/1765/27806 | |
| Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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de Lau, L., van Meurs, J., Uitterlinden, A., Smith, D., Refsum, H., Johnston, C., & Breteler, M. (2010). Genetic variation in homocysteine metabolism, cognition, and white matter lesions. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 31(11), 2020–2022. doi:10.1016/j.neurobiolaging.2008.10.004 |
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