PURPOSE OF REVIEW: To review the recent evidence of the effectiviness of statin therapy in the primary prevention of cardiovascular disease in men and women without established cardiovascular disease (CVD). RECENT FINDINGS: The use of statins in patients without established CVD has important public health implications. Until recently, research has provided ambiguous answers and the reliability of treatment in older people (>65 years), women, and patients with diabetes has remained uncertain, mainly because of a lack of data or inconsistent findings within these clinically defined groups. The Justification for the use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) demonstrated a significant benefit of rosuvastatin in low-risk patients with no apparent vascular disease, low-density lipoprotein levels of less than 3.4 mmol/l, and elevated high sensitivity C-reactive protein. The latest meta-analysis of statins in 70 000 patients without established CVD confirmed the overall benefit of statins in these low-risk patients and found no significant heterogeneity of the treatment effect in the clinically defined subgroups of elderly (>65 years), women, and patients with diabetes. SUMMARY: The use of statins in low-risk patients without CVD remains a matter of intense debate, even following the latest findings from the JUPITER. Statins reduce cardiovascular risk and mortality in this patient category. However, the overall absolute risk reductions and cost-effectiveness of long-term statin prescription should be kept in mind before prescribing statins to relatively healthy individuals. The exact threshold of baseline risk of CVD has not been determined yet and is a challenge for emerging treatment guidelines in primary prevention.

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, cardiovascular disease, primary prevention, statins, stroke
dx.doi.org/10.1097/HCO.0b013e32833cd58f, hdl.handle.net/1765/27855
Current Opinion in Cardiology
Erasmus MC: University Medical Center Rotterdam

Brugts, J.J, & Deckers, J.W. (2010). Statin prescription in men and women at cardiovascular risk: To whom and when?. Current Opinion in Cardiology (Vol. 25, pp. 484–489). doi:10.1097/HCO.0b013e32833cd58f