2010-05-01
Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir
Publication
Publication
AIDS , Volume 24 - Issue 8 p. 1223- 1226
HIV-infected travellers frequently use atovaquone/proguanil as malaria prophylaxis. We compared atovaquone/proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)0→t for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.35-0.83) for patients on efavirenz, lopinavir/ritonavir and atazanavir/ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.
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| doi.org/10.1097/QAD.0b013e3283389129, hdl.handle.net/1765/27864 | |
| AIDS | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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van Luin, M., van der Ende, M., Richter, C., Visser, M., Faraj, D., van der Ven, A., Gelinck, L., Kroon, F., Wit, F., van Schaik, R., Kuks, P.& Burger, D. (2010). Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. AIDS, 24(8), 1223–1226.https://doi.org/10.1097/QAD.0b013e3283389129 |
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