The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30 km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals.

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doi.org/10.1038/ejhg.2010.92, hdl.handle.net/1765/28257
European Journal of Human Genetics
Erasmus MC: University Medical Center Rotterdam

O'Dushlaine, C., McQuillan, R., Weale, M., Crouch, D., Johansson, Å., Aulchenko, Y., Franklin, C., Polasek, O., Fuchsberger, C., Corvin, A., Hicks, A., Vitart, V., Hayward, C., Wild, S., Meitinger, T., Tikka-Kleemola, P., Gyllensten, U., Wright, A., Campbell, H., … Wilson, J. (2010). Genes predict village of origin in rural Europe. European Journal of Human Genetics, 18(11), 1269–1270.https://doi.org/10.1038/ejhg.2010.92