I.M. Heid (Iris),
A.U. Jackson (Anne),
J.C. Randall (Joshua),
T.W. Winkler (Thomas),
L. Qi (Lu),
V. Ssteinthorsdottir (Valgerdur),
G. Tthorleifsson (Ggudmar),
M.C. Zillikens (Carola),
E.K. Sspeliotes (Eelizabeth),
R. Mägi (Reedik),
et al.
T. Workalemahu (Tsegaselassie),
C.C. White (Charles),
N. Bouatia-Naji (Nabila),
T.B. Harris (Tamara),
S.I. Berndt (Sonja),
E. Ingelsson (Erik),
C.J. Willer (Cristen),
J. Luan,
S. Vedantam (Sailaja),
T. Eesko (Tõnu),
T.O. Kilpeläinen (Tuomas),
Z. Kutalik (Zoltán),
S. Li (Shengxu),
K.L. Monda (Keri),
A.L. Dixon (Anna),
C. Holmes (Christopher),
R.C. Kaplan (Robert),
L. Liang (Liming),
J. Min (Josine),
M.F. Moffatt (Miriam),
C. Molony (Cliona),
G. Nicholson (Ggeorge),
E.E. Sschadt (Eeric),
K.T. Zondervan (Krina),
M.F. Feitosa (Mary Furlan),
T. Ferreira (Teresa),
H.L. Allen,
R.J. Weyant (Robert),
E. Wheeler (Eleanor),
A.R. Wood (Andrew),
K. Eestrada (Karol),
M.E. Goddard (Michael),
G. Lettre (Guillaume),
M. Mangino (Massimo),
D.R. Nyholt (Dale),
S. Purcell (Shaun),
A.V. Ssmith,
P.M. Visscher (Peter),
J. Yang (Joanna),
S.A. McCcarroll (Ssteven),
J. Nemesh (James),
B.F. Voight (Benjamin),
D. Absher (Devin),
N. Amin (Najaf),
T. Aspelund (Thor),
L. Coin (Lachlan),
N.L. Glazer (Nicole),
C. Hayward (Caroline),
N. Heard-Ccosta (Nancy),
J.J. Hottenga (Jouke Jan),
A. Johansson (Åsa),
T. Johnson (Toby),
M. Kaakinen (Marika),
K. Kapur (Karen),
S. Ketkar (Shamika),
J.W. Knowles (Joshua),
P. Kraft (Peter),
A. Kraja (Aldi),
C. Lamina (Claudia),
M.F. Leitzmann (Michael),
B. McKknight (Barbara),
A.D. Morris (Andrew),
K. Oong (Ken),
J.R.B. Perry (John),
M.J. Peters (Marjolein),
O. Polasek (Ozren),
I. Prokopenko (Inga),
N.W. Rayner (Nigel William),
S. Ripatti (Samuli),
F. Rivadeneira Ramirez (Fernando),
N.R. Robertson (Neil),
S. Sanna (Serena),
U. Sovio (Ulla),
I. Surakka (Ida),
A. Teumer (Alexander),
S. van Wingerden (Sophie),
V. Vitart (Veronique),
J.H. Zhao (Jing Hua),
C. Cavalcanti-Proença (Christine),
P.S. Chines (Peter),
E. Fisher (Eeva),
J.R. Kulzer (Jennifer),
C. Lecoeur (Cécile),
N. Narisu (Narisu),
C. Sandholt (Camilla),
L.J. Scott (Laura),
K. Silander (Kaisa),
K. Stark (Klaus),
M.L. Tammesoo,
T.M. Teslovich (Tanya),
N.J. Timpson (Nicholas),
R.P. Welch (Ryan),
D.I. Chasman (Daniel),
M.N. Cooper (Matthew),
J.O. Jansson,
J. Kettunen (Johannes),
R. Wlawrence (Robert),
N. Pellikka (Niina),
M. Perola (Markus),
L. Vandenput (Liesbeth),
H. Alavere (Helene),
P. Almgren (Peter),
L.D. Atwood (Larry),
A.J. Bennett (Amanda),
R. Biffar (Reiner),
L.L. Bonnycastle (Lori),
S.R. Bornstein (Stefan),
T.A. Buchanan (Thomas),
H. Campbell (Harry),
I.N.M. Day (Ian),
M. Dei (Mariano),
M. Dörr (Marcus),
P. Eelliott (Paul),
M.R. Eerdos (Micheal),
J.G. Eeriksson (Johan),
N.B. Freimer (Nelson),
M. Fu (Mao),
S. Gaget (Stefan),
E.J.C. de Geus (Eco),
A.P. Gjesing (Anette),
H. Grallert (Harald),
J. Gräßler (Jürgen),
C.J. Groves (Christopher),
C. Guiducci (Candace),
A.L. Hartikainen,
N. Hassanali (Neelam),
A.S. Havulinna (Aki),
K.H. Herzig,
A.A. Hicks (Andrew),
J. Hui (Jennie),
W. Igl (Wilmar),
P. Jousilahti (Pekka),
A. Jula (Antti),
E. Kajantie (Eero),
L. Kinnunen (Leena),
I. Kolcic (Ivana),
S. Koskinen (Seppo),
P. Kovacs (Peter),
H.K. Kroemer (Heyo),
V. Krzelj (Vjekoslav),
J. Kuusisto (Johanna),
K. Kvaløy (Kirsti),
J. Laitinen (Jaana),
O. Lantieri (Olivier),
G.M. Lathrop (Mark),
M.L. Lokki,
R.N. Luben (Robert),
B. Ludwig (Barbara),
W.L. McArdle (Wendy),
A. McCcarthy (Anne),
M.A. Morken (Mario),
M. Nelis (Mari),
M.J. Neville (Matthew),
G. Paré (Guillaume),
A.N. Parker (Alex),
J. Peden (John),
I. Pichler (Irene),
K.H. Pietilainen (Kirsi Hannele),
C.P. Platou (Carl),
A. Pouta (Anneli),
M. Ridderstråle (Martin),
N.J. Samani (Nilesh),
J. Saramies (Jouko),
J. Sinisalo (Juha),
J.H. Smit (Jan),
R.J. Strawbridge (Rona),
H.M. Stringham (Heather),
A.J. Swift (Amy),
M. Teder-Llaving (Maris),
B. Thomson (Brian),
G. Usala,
J.B.J. van Meurs (Joyce),
G.J. van Ommen (Gert),
V. Vatin (Vincent),
C.B. Volpato,
H. Wallaschofski (Henri),
G.B. Walters (Bragi),
E. Widen (Elisabeth),
S.H. Wild (Sarah),
G.A.H.M. Willemsen (Gonneke),
D.R. Witte (Deniel),
L. Zgaga (Lina),
P. Zitting (Paavo),
J.P. Beilby (John),
A. James (Alan),
M. Kähönen (Mika),
T. Lehtimäki (Terho),
M.S. Nieminen (Markku),
C. Ohlsson (Claes),
C. Palmer (Cameron),
O. Raitakari (Olli),
P.M. Ridker (Paul),
M. Stumvoll (Michael),
A. Tönjes (Anke),
J. Viikari (Jorma),
B. Balkau (Beverley),
Y. Ben-Shlomo,
R.N. Bergman (Richard),
H. Boeing (Heiner),
A.V. Smith (Albert Vernon),
S. Eebrahim (Shah),
P. Froguel (Philippe),
T. Hansen (Torben),
C. Hengstenberg (Christian),
K. Hveem (Kristian),
B. Isomaa (Bo),
T. Jørgensen (Torben),
F. Karpe (Fredrik),
K-T. Khaw (Kay-Tee),
M. Laakso (Markku),
D.A. Lawlor (Debbie),
M. Marre (Michel),
T. Meitinger (Thomas),
A. Metspalu (Andres),
K. Midthjell (Kristian),
O. Pedersen (Oluf),
V. Salomaa (Veikko),
P.E.H. Schwarz (Peter),
T. Tuomi (Tiinamaija),
J. Tuomilehto (Jaakko),
T.T. Valle (Timo),
N.J. Wareham (Nick),
A.M. Arnold (Alice),
J.S. Beckmann (Jacques),
S.M. Bergmann (Sven),
E.A. Boerwinkle (Eric),
D.I. Boomsma (Dorret),
M. Caulfield (Mark),
F.S. Collins (Francis),
G. Eeiriksdottir (Gudny),
V. Gudnason (Vilmundur),
U. Gyllensten (Ulf),
A. Hamsten (Anders),
A.T. Hattersley (Andrew),
A. Hofman (Albert),
F.B. Hu (Frank),
T. Illig (Thomas),
C. Iribarren (Carlos),
M.R. Järvelin,
W.H.L. Kao (Wen),
J. Kaprio (Jaakko),
L.J. Launer (Lenore),
P. Munroe (Patricia),
B.A. Oostra (Ben),
B.W.J.H. Penninx (Brenda),
P.P. Pramstaller (Peter Paul),
B.M. Psaty (Bruce),
T. Quertermous (Thomas),
A. Rissanen (Aila),
I. Rudan (Igor),
A.R. Shuldiner (Alan),
N. Soranzo (Nicole),
T.D. Spector (Timothy),
A.C. Syvanen,
M. Uda (Manuela),
A.G. Uitterlinden (André),
H. Völzke (Henry),
P. Vollenweider (Peter),
J.F. Wilson (James),
J.C.M. Witteman (Jacqueline),
A.F. Wright (Alan),
G.R. Abecasis (Gonçalo),
M. Boehnke (Michael),
I.B. Borecki (Ingrid),
P. Deloukas (Panagiotis),
T.M. Frayling (Timothy),
L. Groop (Leif),
T. Haritunians (Talin),
D.J. Hunter (David),
K.E. North (Kari),
J.R. O'Cconnell (Jeffrey),
L. Peltonen (Leena Johanna),
D. Schlessinger,
D.P. Strachan (David),
J.N. Hirschhorn (Joel),
T.L. Assimes (Themistocles),
H.E. Wichmann (Heinz Erich),
U. Thorsteinsdottir (Unnur),
C.M. van Duijn (Cornelia),
K. Stefansson (Kari),
L.A. Cupples (Adrienne),
R.J.F. Loos (Ruth),
I.E. Barroso (Inês),
C.S. Fox (Caroline),
K.L. Mohlke (Karen),
C.M. Lindgren (Cecilia),
R.M. Watanabe (Richard)
and
M.N. Weedon (Michael)
2010-11-01
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Publication
Publication
Nature Genetics , Volume 42 - Issue 11 p. 949- 960
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9-10-9 to P = 1.8-10-40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9-10-3 to P = 1.2-10-13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Additional Metadata | |
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Persistent URL | doi.org/10.1038/ng.685, hdl.handle.net/1765/28358 |
Journal | Nature Genetics |
Note | Free full text at PubMed |
Grant | This work was funded by the European Commission 7th Framework Programme; grant id fp7/201413 - European Network for Genetic and Genomic Epidemiology (ENGAGE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/212111 - Biobanking and Biomolecular Resources Research Infrastructure (BBMRI), This work was funded by the European Commission 7th Framework Programme; grant id fp7/205419 - Unlocking the European Union convergence region potential in genetics (ECOGENE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/245536 - Opening Estonian Genome Project for European Research Area (OPENGENE) |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Citation |
Heid, I., Jackson, A., Randall, J., Winkler, T., Qi, L., Ssteinthorsdottir, V., … Weedon, M. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nature Genetics, 42(11), 949–960. doi:10.1038/ng.685 |