Double-dose hepatitis B virus revaccination of human immunodeficiency virus (HIV)-infected patients proved to be effective in 50.7% of 144 patients who had previously failed to respond to standard doses. In the multivariate analysis, female patients were found to have a significantly better response (P = .03). The effect of age on the response depended on the viral load at the time of revaccination. For patients with a detectable HIV RNA load, the effect of age was stronger (odds ratio [OR], 0.34 per 10 years older [95% confidence interval {CI}, 0.16-0.72]; P = .005) than for patients with an undetectable HIV RNA load (OR, 0.74 per 10 years older [95% CI, 0.50-1.09]; P = .12).

dx.doi.org/10.1086/524690, hdl.handle.net/1765/29158
The Journal of Infectious Diseases
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Erasmus MC: University Medical Center Rotterdam

de Vriessluijs, T.E.M.S, Hansen, B.E, van Doornum, G.J.J, Springeling, T, Evertsz, N.M, de Man, R.A, & van der Ende, M.E. (2008). A prospective open study of the efficacy of high-dose recombinant hepatitis B rechallenge vaccination in HIV-infected patients. The Journal of Infectious Diseases, 197(2), 292–294. doi:10.1086/524690