In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

Childhood leukemia, Cortivazol, Glucocorticoid resistance, Meta-iodobenzylguanidine
dx.doi.org/10.1016/j.leukres.2008.02.009, hdl.handle.net/1765/29419
Leukemia Research: clinical and laboratory studies
Erasmus MC: University Medical Center Rotterdam

Haarman, E.G, Kaspers, G.J.L, Pieters, R, Rottier, M.M.A, & Veerman, A.J.P. (2008). Circumvention of glucocorticoid resistance in childhood leukemia. Leukemia Research: clinical and laboratory studies, 32(9), 1417–1423. doi:10.1016/j.leukres.2008.02.009