Autograft or allograft aortic valve replacement in young adult patients with congenital aortic valve disease
European Heart Journal , Volume 29 - Issue 11 p. 1446- 1453
Aims: We analysed the outcome of young adults with congenital aortic valve disease who underwent allograft or autograft aortic valve or root replacement in our institution and evaluated whether there is a preference for either valve substitute. Methods and results: Between 1987 and 2007, 169 consecutive patients with congenital aortic valve disease aged 16-55, participating in our ongoing prospective follow-up study, underwent 63 autograft and 106 allograft aortic valve replacements (AVRs). Mean age was 35 years (SD 10.8), 71% were males. Aetiology was 71% bicuspid valve, 14% other congenital, and 15% BV endocarditis. Twenty-two percent underwent previous cardiac surgery; 11% had an ascending aorta aneurysm. Two patients died in hospital. During follow-up six more patients died and 45 patients required valve-related re-operations. Thirteen-year survival was 97% for autograft and 93% for allograft recipients, 13 year freedom from valve-related re-operation was 63% for autograft and 69% for allograft patients. Conclusion: In patients with congenital aortic valve disease, autograft and allograft AVR show comparable satisfactory early and long-term results, with the increasing re-operation risk in the second decade after operation remaining a major concern.
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|European Heart Journal|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Klieverik, L.M.A, Bekkers, J.A, Roos, J.W, Eijkemans, M.J.C, Raap, G.B, Bogers, A.J.J.C, & Takkenberg, J.J.M. (2008). Autograft or allograft aortic valve replacement in young adult patients with congenital aortic valve disease. European Heart Journal, 29(11), 1446–1453. doi:10.1093/eurheartj/ehm589