The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbSβ0-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbSβ+-thalassemia 0.23L, 0.0-0.58) compared with controls (1×109L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.

doi.org/10.3324/haematol.12027, hdl.handle.net/1765/29628
Haematologica
Erasmus MC: University Medical Center Rotterdam

van Beers, E.J, Nieuwdorp, M, Duits, A.J, Evers, L.M, Schnog, J.J.B, & Biemond, B.J. (2008). Sickle cell patients are characterized by a reduced glycocalyx volume. Haematologica, 93(2), 307–308. doi:10.3324/haematol.12027