White matter injury and abnormal maturation are thought to be major contributors to the neurodevelopmental disabilities observed in children and adolescents who were born preterm. Early detection of abnormal white matter maturation is important in the design of preventive, protective, and rehabilitative strategies for the management of the preterm infant. Diffusion Tensor Imaging (DTI) allows non-invasive, in vivo visualization and quantification of white matter tracts and has become a valuable tool in assessing white matter maturation in children born preterm. We will review the use of DTI to study white matter maturation and injury in the preterm brain.

Brain, Diffusion tensor imaging, Neonate, Preterm
dx.doi.org/10.1016/j.earlhumdev.2008.09.004, hdl.handle.net/1765/29712
Early Human Development
Erasmus MC: University Medical Center Rotterdam

Dudink, J, Kerr, J.L, Paterson, K, & Counsell, S.J. (2008). Connecting the developing preterm brain. Early Human Development, 84(12), 777–782. doi:10.1016/j.earlhumdev.2008.09.004