Topotecan distribution in an anephric infant with therapy resistant bilateral Wilms tumor with a novel germline WT1 gene mutation
Cancer Chemotherapy and Pharmacology , Volume 62 - Issue 6 p. 1039- 1044
The therapeutic strategy for bilateral Wilms tumor (WT) remains a challenge. Especially in cases with chemotherapy resistant disease, bilateral nephrectomy is sometimes inevitable. For optimal cure rates stage V WT patients benefit from adjuvant treatment; however, there are limited data available on chemotherapy pharmacokinetics in anephric children. In this report, we describe a 10-month old girl with bilateral Wilms tumor and a novel germline WT1 gene mutation. This patient hardly showed any response on preoperative chemotherapy, and ultimately, underwent sequential bilateral tumor-nephrectomy. Subsequently, during peritoneal dialysis, she received topotecan as adjuvant chemotherapy based on plasma levels, indicating that this is a reasonable option as adjuvant treatment in therapy-resistant Wilms tumor patients after bilateral nephrectomy. This case showed a novel germline WT1 gene mutation of which the correlation with resistant phenotype has to be confirmed in larger cohorts of WT patients.
|Anephric infant, Bilateral Wilms tumor, Novel WT1 mutation, Therapy resistance, Topotecan|
|Cancer Chemotherapy and Pharmacology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Lugtenberg, R.T, Cransberg, K, Loos, W.J, Wagner, A, Alders, M, & van den Heuvel-Eibrink, M.M. (2008). Topotecan distribution in an anephric infant with therapy resistant bilateral Wilms tumor with a novel germline WT1 gene mutation. Cancer Chemotherapy and Pharmacology, 62(6), 1039–1044. doi:10.1007/s00280-008-0694-x