Fine-tuning of hematopoietic stem cell homeostasis: Novel role for ubiquitin ligase

Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (pp. 992-997) report a new player in HSC homeostasis, c-Cbl ubiq-uitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.

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