Objective: We investigate the implications of high magnetic field strength on MR venography based on susceptibility-weighted imaging (SWI) and estimate the optimum echo time to obtain maximum contrast between blood and brain tissue. Materials and methods: We measured tissue contrast and T*2relaxation times at 7 T of gray matter, white matter, and venous blood in vivo. Results: T*2relaxation times of gray matter, white matter, and venous blood in vivo yielded 32.9 ± 2.3, 27.7 ± 4.3, and 7.4 ± 1.4 ms, respectively. Optimum TE was found to be 15 ms which is supported by theoretical considerations. Using this optimum TE, we acquired 3D high resolution datasets with a large volume coverage in a short measurement time that show very detailed microanatomical structures of the human brain such as intracortical veins and laminar cortical substructures. Conclusions: By applying optimised vessel filters (vesselness filter and vessel enhancing diffusion) whole brain MR venograms can be obtained at 7 T with a significantly reduced measurement time compared to 3 T.

3 T, 7 T, Neuroimaging, Parallel imaging, Transverse relaxation times, Venography, Vessel enhancing diffusion, Vessel segmentation
dx.doi.org/10.1007/s10334-007-0101-3, hdl.handle.net/1765/29999
Magnetic Resonance Materials in Physics, Biology and Medicine
Erasmus MC: University Medical Center Rotterdam

Koopmans, P.J, Manniesing, R, Niessen, W.J, Viergever, M.A, & Barth, M. (2008). MR venography of the human brain using susceptibility weighted imaging at very high field strength. Magnetic Resonance Materials in Physics, Biology and Medicine, 21(1-2), 149–158. doi:10.1007/s10334-007-0101-3