General aspects of strategies for the isolation of mammalian DNA repair genes using DNA mediated gene transfer to repair deficient mutant cells are discussed with emphasis on the possibilities and limitations of the technique as well as potential problems and pitfalls. A summary is given of results obtained thusfar using this approach.

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Annali dell’Istituto Superiore di Sanità
Erasmus MC: University Medical Center Rotterdam

van Duin, M, & Hoeijmakers, J.H.J. (1989). Cloning of human repair genes by genomic DNA transfection. Annali dell’Istituto Superiore di Sanità, 25(1), 131–142. Retrieved from