In this issue of Molecular Cell, Barlow et al. (2008) show that not all DNA double-strand breaks are processed equally and that the chemical nature of DNA ends guides different paths to DNA repair.

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Journal Molecular Cell
Wyman, C, Warmerdam, D.O, & Kanaar, R. (2008). From DNA End Chemistry to Cell-Cycle Response: The Importance of Structure, Even When It's Broken. Molecular Cell, 30(1), 5–6. doi:10.1016/j.molcel.2008.03.007