2008-12-01
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
Publication
Publication
Nature Genetics , Volume 40 - Issue 12 p. 1402- 1403
The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 × 10-10). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.
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| doi.org/10.1038/ng.251, hdl.handle.net/1765/30208 | |
| Nature Genetics | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Aulchenko, Y., Hoppenbrouwers, I., Ramagopalan, S., Broer, L., Jafari, N., Hillert, J., Link, J., Lundström, W., Greiner, E., Dessa Sadovnick, A., Goossens, D., van Broeckhoven, C., Del-Favero, J., Ebers, G. C., Oostra, B., Tikka-Kleemola, P.& Hintzen, R. (2008). Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nature Genetics, 40(12), 1402–1403.https://doi.org/10.1038/ng.251 |
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