Modulation of the cellular immune system by intravenous immunoglobulin
Trends in Immunology , Volume 29 - Issue 12 p. 608- 615
Intravenous immunoglobulin (IVIg) is therapeutically used in a variety of immune-mediated diseases. The beneficial effects of IVIg in auto-antibody-mediated diseases can be explained by neutralization, accelerated clearance and prevention of Fcγ-receptor binding of auto-antibodies. However, the means by which IVIg exerts therapeutic effects in disorders mediated by cellular immunity have remained enigmatic. Clinical improvements, followed by IVIg treatment, often extend beyond the half-life of infused IgG, thereby indicating that IVIg modifies the cellular immune compartment for a prolonged period. Here, we discuss recent advances in the understanding of different, mutually non-exclusive mechanisms of action of IVIg on cells of the innate and adaptive immune system. These mechanisms might explain the beneficial effects of IVIg in certain autoimmune and inflammatory diseases.
|Trends in Immunology|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Tha-In, T, Bayry, J, Metselaar, H.J, Kaveri, S.V, & Kwekkeboom, J. (2008). Modulation of the cellular immune system by intravenous immunoglobulin. Trends in Immunology (Vol. 29, pp. 608–615). doi:10.1016/j.it.2008.08.004