Non-human primate models of multiple sclerosis
Because of their outbred nature and close genetic and immunological proximity to humans, non-human primates offer unique models for translational research into autoimmune-mediated inflammatory disorders. This review discusses non-human primate models of multiple sclerosis (MS), a progressive neurological disorder with a high unmet need for effective treatment. These models can help to bridge the gap between rodent experimental autoimmune encephalomyelitis (EAE) models and patients, which is a main cause of the present high attrition rate of new treatments.
|Persistent URL||dx.doi.org/10.1016/j.ddmod.2008.06.001, hdl.handle.net/1765/30498|
|Journal||Drug Discovery Today: Disease Models|
't Hart, B.A, & Bajramovic, J.J. (2008). Non-human primate models of multiple sclerosis. Drug Discovery Today: Disease Models (Vol. 5, pp. 97–104). doi:10.1016/j.ddmod.2008.06.001