Giving a patient immunosuppressive medication is creating an environment in which a transplanted organ will be accepted and rejection will be prevented. Unfortunately, the use of immunosuppression is complicated by serious side effects. After dealing with acute rejection in solid organ transplantation and reducing the incidence of infections in the early days of transplantation, other serious complications became more and more clear. The development of, for example, cardiovascular disease, diabetes mellitus, nephrotoxicity and malignancies after solid organ transplantation is a well known problem for every transplant clinician.

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W. Weimar (Willem)
Erasmus University Rotterdam
The publication of this thesis was financially supported by: Astellas Pharma, Genzyme Nederland, Merck Sharp & Dohme, Nederlandse Transplantatie Vereniging, Novartis Pharma, Pfizer, Roche Nederland
Erasmus MC: University Medical Center Rotterdam

van de Wetering, J. (2011, November 24). Rationale and effect of reduction of immunosuppressive load in organ transplant recipients. Erasmus University Rotterdam. Retrieved from