The median survival of glioma patient is still very poor and new therapeutic targets have to be discovered. The aim of this thesis is to identify genetic alterations in glioma and functionally characterize the most promising candidates. We describe several novel methods used to identify these mutations.

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P.A.E. Sillevis Smitt (Peter) , C.C. Hoogenraad (Casper)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam