2011-12-21
The Il-IL/23-17 Immune Pathway in Arthritis
Publication
Publication
De IL-23/IL-17 immuun route in artritis
Rheumatoid arthritis (RA) was originally thought to be a T-helper (Th)1- but not a Th2- associated disorder; however, it currently is unclear whether RA is a Th1- and/or Th17- mediated disease, and what the contributions of these T-cell subsets are in the pathogenesis of RA. Results from studies using different arthritis models have demonstrated that IL-17- producing T-cells are the dominant cell type in the development of arthritis. In addition, a critical role of the IL-23/IL-17 axis in the progression to chronic destructive arthritis has been demonstrated. Interestingly, Th1 and Th17 cells both may have unique pathogenic potential, and the recent insights into T-cell plasticity may change the understanding of the role of T-cell subsets in chronic autoimmune diseases.
| Additional Metadata | |
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| , , | |
| J.M.W. Hazes (Mieke) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/30678 | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Cornelissen, F. (2011, December 21). The Il-IL/23-17 Immune Pathway in Arthritis. Retrieved from http://hdl.handle.net/1765/30678 |
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| Additional Files | |
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| 3446_Cornelissen, Fredericus Hermanus Johannes.jpg Cover Image , 25kb | |
| Cornelissen Stellingen.pdf , 14kb | |
