Rheumatoid arthritis (RA) was originally thought to be a T-helper (Th)1- but not a Th2- associated disorder; however, it currently is unclear whether RA is a Th1- and/or Th17- mediated disease, and what the contributions of these T-cell subsets are in the pathogenesis of RA. Results from studies using different arthritis models have demonstrated that IL-17- producing T-cells are the dominant cell type in the development of arthritis. In addition, a critical role of the IL-23/IL-17 axis in the progression to chronic destructive arthritis has been demonstrated. Interestingly, Th1 and Th17 cells both may have unique pathogenic potential, and the recent insights into T-cell plasticity may change the understanding of the role of T-cell subsets in chronic autoimmune diseases.

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J.M.W. Hazes (Mieke)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Cornelissen, F.H.J. (2011, December 21). The Il-IL/23-17 Immune Pathway in Arthritis. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/30678