Recently published crystal structures of different Mre11 and Rad50 complexes show the arrangement of these proteins and imply dramatic ligand-induced rearrangements with important functional consequences.

DNA double-strand breaks, DNA repair, Genome maintenance
dx.doi.org/10.1016/j.dnarep.2011.07.008, hdl.handle.net/1765/30774
Mutation Research - DNA Repair
This work was funded by the European Commission 7th Framework Programme; grant id fp7/259893 - The DNA damage response and breast cancer (DDRESPONSE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/223545 - Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance (MISMATCH2MODEL)
Erasmus MC: University Medical Center Rotterdam

Wyman, C, Lebbink, J.H.G, & Kanaar, R. (2011). Mre11-Rad50 complex crystals suggest molecular calisthenics. Mutation Research - DNA Repair, 10(10), 1066–1070. doi:10.1016/j.dnarep.2011.07.008