Mre11-Rad50 complex crystals suggest molecular calisthenics
Mutation Research - DNA Repair , Volume 10 - Issue 10 p. 1066- 1070
Recently published crystal structures of different Mre11 and Rad50 complexes show the arrangement of these proteins and imply dramatic ligand-induced rearrangements with important functional consequences.
|DNA double-strand breaks, DNA repair, Genome maintenance|
|Mutation Research - DNA Repair|
|This work was funded by the European Commission 7th Framework Programme; grant id fp7/259893 - The DNA damage response and breast cancer (DDRESPONSE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/223545 - Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance (MISMATCH2MODEL)|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Wyman, C, Lebbink, J.H.G, & Kanaar, R. (2011). Mre11-Rad50 complex crystals suggest molecular calisthenics. Mutation Research - DNA Repair, 10(10), 1066–1070. doi:10.1016/j.dnarep.2011.07.008