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C. Wyman (Claire), J.H.G. Lebbink (Joyce) and R. Kanaar (Roland)

2011-10-10

Mre11-Rad50 complex crystals suggest molecular calisthenics

Publication

Publication

Mutation Research - DNA Repair , Volume 10 - Issue 10 p. 1066- 1070

Recently published crystal structures of different Mre11 and Rad50 complexes show the arrangement of these proteins and imply dramatic ligand-induced rearrangements with important functional consequences.

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Keywords DNA double-strand breaks, DNA repair, Genome maintenance
Persistent URL doi.org/10.1016/j.dnarep.2011.07.008, hdl.handle.net/1765/30774
Journal Mutation Research - DNA Repair
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/259893 - The DNA damage response and breast cancer (DDRESPONSE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/223545 - Characterization and quantitative modeling of DNA mismatch repair and its role in the maintenance of genomic stability and cancer avoidance (MISMATCH2MODEL)
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Wyman, C., Lebbink, J., & Kanaar, R. (2011). Mre11-Rad50 complex crystals suggest molecular calisthenics. Mutation Research - DNA Repair, 10(10), 1066–1070. doi:10.1016/j.dnarep.2011.07.008
Free Full Text (Manuscript at PubMed Central)


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