Recently published crystal structures of different Mre11 and Rad50 complexes show the arrangement of these proteins and imply dramatic ligand-induced rearrangements with important functional consequences.

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Mutation Research - DNA Repair
Erasmus MC: University Medical Center Rotterdam

Wyman, C., Lebbink, J., & Kanaar, R. (2011). Mre11-Rad50 complex crystals suggest molecular calisthenics. Mutation Research - DNA Repair, 10(10), 1066–1070. doi:10.1016/j.dnarep.2011.07.008