Study Type - Aetiology (individual cohort) Level of Evidence2b What's known on the subject? and What does the study add? Recent studies have already shown associations between generalized joint hypermobility (GJH) and voiding and defecation dysfunction and/or slow transit constipation. Changes in extracellular matrix composition in vesico-ureteric junction of vesico-ureteral reflux (VUR) patients were also observed previously. This study is the first to assess joint mobility as a parameter for connective tissue composition in vesico-ureteral reflux. We convincingly demonstrate that VUR patients have significantly more hypermobile joints compared to controls and this provides a new angle to the intriguing subjects of development of VUR and susceptibility to VUR. Objective: To assess whether there is an increased prevalence of joint hypermobility in patients with vesico-ureteric reflux (VUR). Materials And Methods: We studied 50 patients with primary VUR and matched controls drawn from a reference population. Joint mobility was assessed using the Bulbena hypermobility score. RESULTS: We identified significantly more patients with VUR with generalized joint hypermobility than controls (24% vs 6.7%, P= 0.007). Conclusion: Our findings confirm our clinical observation of an increased rate of joint hypermobility in patients with VUR. We speculate that an altered composition of the connective tissue may contribute to the severity of the (pre-existing) VUR phenotype. © 2011 THE AUTHORS. BJU INTERNATIONAL

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BJU International
Erasmus MC: University Medical Center Rotterdam

van Eerde, A., Verhoeven, V., de Jong, T. P. V. M., van de Putte, E., Giltay, J., & Engelbert, R. (2012). Is joint hypermobility associated with vesico-ureteral reflux? An assessment of 50 patients. BJU International, 109(8), 1243–1248. doi:10.1111/j.1464-410X.2011.10469.x