Chemoradiation (CRT) is a valuable treatment option for advanced hypopharyngeal squamous cell cancer (HSCC). However, long-term toxicity and quality of life (QOL) is scarcely reported. Therefore, efficacy, acute and long-term toxic effects, and long-term QOL of CRT for advanced HSCC were evaluated,using retrospective study and post-treatment quality of life questionnaires. in a tertiary hospital setting. Analysis was performed of 73 patients that had been treated with CRT. Toxicity was rated using the CTCAE score list. QOL questionnaires EORTC QLQ-C30, QLQ-H&N35, and VHI were analyzed. The most common acute toxic effects were dysphagia and mucositis. Dysphagia and xerostomia remained problematic during long-term follow-up. After 3 years, the disease-specific survival was 41%, local disease control was 71%, and regional disease control was 97%. The results indicated that CRT for advanced HSCC is associated with high locoregional control and disease-specific survival. However, significant acute and long-term toxic effects occur, and organ preservation appears not necessarily equivalent to preservation of function and better QOL.

Chemoradiation, Head and neck cancer, Hypopharyngeal carcinoma, Quality of life,
European Archives of Oto-Rhino-Laryngology
Erasmus MC: University Medical Center Rotterdam

Keereweer, S, Kerrebijn, J.D.F, Al-Mamgani, A, Sewnaik, A, de Jong, R.J.B, & van Meerten, E. (2012). Chemoradiation for advanced hypopharyngeal carcinoma: a retrospective study on efficacy, morbidity and quality of life. European Archives of Oto-Rhino-Laryngology, 269(3), 939–946. doi:10.1007/s00405-011-1694-8