Chemoradiation (CRT) is a valuable treatment option for advanced hypopharyngeal squamous cell cancer (HSCC). However, long-term toxicity and quality of life (QOL) is scarcely reported. Therefore, efficacy, acute and long-term toxic effects, and long-term QOL of CRT for advanced HSCC were evaluated,using retrospective study and post-treatment quality of life questionnaires. in a tertiary hospital setting. Analysis was performed of 73 patients that had been treated with CRT. Toxicity was rated using the CTCAE score list. QOL questionnaires EORTC QLQ-C30, QLQ-H&N35, and VHI were analyzed. The most common acute toxic effects were dysphagia and mucositis. Dysphagia and xerostomia remained problematic during long-term follow-up. After 3 years, the disease-specific survival was 41%, local disease control was 71%, and regional disease control was 97%. The results indicated that CRT for advanced HSCC is associated with high locoregional control and disease-specific survival. However, significant acute and long-term toxic effects occur, and organ preservation appears not necessarily equivalent to preservation of function and better QOL.

Chemoradiation, Head and neck cancer, Hypopharyngeal carcinoma, Quality of life
dx.doi.org/10.1007/s00405-011-1694-8, hdl.handle.net/1765/31294
European Archives of Oto-Rhino-Laryngology
Erasmus MC: University Medical Center Rotterdam

Keereweer, S, Kerrebijn, J.D.F, Al-Mamgani, A, Sewnaik, A, de Jong, R.J.B, & van Meerten, E. (2012). Chemoradiation for advanced hypopharyngeal carcinoma: a retrospective study on efficacy, morbidity and quality of life. European Archives of Oto-Rhino-Laryngology, 269(3), 939–946. doi:10.1007/s00405-011-1694-8