lymphoid organs are generally subdivided into two groups according to their contribution to antibody formation: 'primary 1 and 'secondari lymphoid organs. In mammals bone marrow and thymus are considered to be 'primar/ because these organs are involved in the generation of lymphocytes: B cells and T cells respectively. These lymphocytes can ieave t·heir place of origin and provide for antibody formation in secondary lymphoid organs: sp!een, lymph nodesr Peyer1s patches and other gut-associated lymphoid tissue. After antigenic stimulation B cells can potentialfy differentiate into antibody producing plasma cells. T cells play a principal role in cell-mediated immune responses, which include delayed hypersensitivity, contact sensitivity, graft rejection, graft-versus-host responses and acquired resistance to some microbes. In addition to be involved in cell-mediated immunity T cells cooperate with B cells in antibody formation to most antigens. Thereby T cells can enhance and suppress the response of the B cells to the antigen. Antigens which reguire cooperation of B cells and T celfs to evoke antibody formation are called 1thymus-dependent1 antigens in contrast to 1thymus-independent1 antigens which do not require T cells for antibody formation. There are suggestions in the I iterature that antibody formation in mammals can take place not only in secondary lymphoid organs but also in bone marrow:

Additional Metadata
Keywords bone marrow, mouse
Promotor O. Vos
Publisher Erasmus University Rotterdam
Persistent URL
Benner, R. (1975, October 15). Antibody formation in mouse bone marrow. Erasmus University Rotterdam. Retrieved from