Aim: Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions. Methods: 60 male type 2 diabetes patients (HbA1c7.5±0.1% [58±1mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring. Results: Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10mmol/L) 38±4% of the day. Even diabetes patients with an HbA1clevel below 7.0% (53mmol/mol) experienced hyperglycemia for as much as 24±5% throughout the day. Hyperglycemia was negligible in the control group (3±1%). Conclusion: Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA1clevel well below 7.0% (53mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.

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Diabetes Research and Clinical Practice
Erasmus MC: University Medical Center Rotterdam

van Dijk, H., Manders, R. J. F., Hartgens, F., Stehouwer, C., Praet, S., & van Loon, L. (2011). Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Research and Clinical Practice, 93(1), 31–37. doi:10.1016/j.diabres.2011.03.021