Potent inhibitors of nitric oxide synthase (NOS), 3-bromo-7-nitro indazole, 1-(2-trifluoromethylphenyl)imidazole, S-methyl-thiocitrulline and 7-nitro indazole, reduced locomotion in mice. These results suggest that activity of NOS and corresponding NO release are of importance for normal locomotion.

1-(2-Trifluoromethylphenyl)imidazole, 3-Bromo-7-nitro indazole, 7-Nitro indazole, Locomotion, Mice, NO synthase inhibitors, S-Methyl-L-thiocitrulline
dx.doi.org/10.1016/S0166-4328(97)02281-X, hdl.handle.net/1765/31867
Behavioural Brain Research
Erasmus MC: University Medical Center Rotterdam

Dzoljic, E, & de Vries, R.R.P. (1997). New and potent inhibitors of nitric oxide synthase reduce motor activity in mice. Behavioural Brain Research, 87(2), 209–212. doi:10.1016/S0166-4328(97)02281-X