The distribution of GABA in lumbar motoneuronal cell groups. A quantitative ultrastructural study in rat
Brain Research , Volume 530 - Issue 1 p. 130- 137
γ-Aminobutyric acid (GABA)-containing profiles were identified at the ultrastructural level in rat lumbar motoneuronal cell groups by means of the postembedding immunogold technique, which is assumed to give very accurate quantitative results. It was found that 84.5% of the GABA-labeled terminals were of F-type (containing many flattened vesicles), whereas P-type terminals (presynaptic to other terminals) constituted 9.2% of the GABAergic terminal profiles. A few of the GABA-labeled terminal profiles (1.7%) were G-type (containing many granular vesicles and presumed serotonergic), possibly indicating co-existence of GABA and serotonin. It is concluded that in spinal motoneuronal cell groups the large majority of the GABAergic terminal profiles were involved in postsynaptic inhibition of motoneurons, while only a minority was engaged in presynaptic inhibition.
|Organisation||Erasmus MC: University Medical Center Rotterdam|
The distribution of GABA in lumbar motoneuronal cell groups. A quantitative ultrastructural study in rat. (1990). The distribution of GABA in lumbar motoneuronal cell groups. A quantitative ultrastructural study in rat. Brain Research, 530(1), 130–137. doi:10.1016/0006-8993(90)90669-3