Allo-antigen dependent and independent factors early after heart transplantation lead to a response-to-injury mechanism that may determine later outcome in terms of acute rejection, chronic rejection, graft dysfunction, and mortality. 13·24'30'53 The aim of this thesis is to elucidate the role of cytokines in the cascade of events that lead to acute rejection, chronic rejection and graft dysfunction after heart transplantation. We hypothesize that intragraft cytokine mRNA expression patterns are related to acute cellular rejection, early signs of chronic rejection, and to changes in graft dimensions and function. In addition, the role of ischemia, immunosuppressive therapy, and apoptosis in mediating the immune response is studied.

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W. Weimar (Willem)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

de Groot-Kruseman, H. A. (2002, December 4). Cytokines and graft function in heart transplant recipients. Retrieved from