In the past decade, in vitro colony culture methods have been developed to study cellular proliferation and differentiation in hematopoiesis. The application of these culture methods in human myeloid leukemia revealed several disturbances in the hematopoietic stem cell campartment of these neeplastic diseases. It has been the general finding that acute leukemia cells lack the ability to produce colanies in the culture systems designed for the growth of progenitor cells in normal hematopoiesis. Our investigations intended to develop a colony culture system specific for leukemie progenitor cells and to characterize these cells in order to get some insight into pathophysiological events in leukernia.

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J. Abels (Lyanne)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Swart, K. (1982, December). Progenitor cells in human myeloid leukemia : in vitro studies with PHA supplemented colony cultures. Retrieved from