2012-06-01
Dissection of the Complex Genetic Architecture of Human Stature and Osteoporosis
Publication
Publication
Ontrafeling van de complexe genetische architectuur van menselijke lengte en osteoporose
Osteoporosis is a common complex disease mostly characterized by decreased bone mineral density (BMD). In this thesis we show that hundreds of variants affect adult height and it is the same case for many other complex traits such as bone mineral density. We have applied the novel hypothesis-free approach of Genome-wide Association Study (GWAS) to identify those loci harboring at least one variant affecting these osteoporosis-related traits.
| Additional Metadata | |
|---|---|
| Keywords | bone, fracture, genetics, height, osteoporosis, stature |
| Promotor | A.G. Uitterlinden (André) |
| Publisher | Erasmus University Rotterdam |
| ISBN | 978-94-6169-246-7 |
| Persistent URL | hdl.handle.net/1765/32475 |
| Grant | This work was funded by the European Commission 7th Framework Programme; grant id fp7/201865 - GENETIC FACTORS FOR OSTEOPOROSIS (GEFOS), This work was funded by the European Commission 7th Framework Programme; grant id fp7/223004 - A PHArmacogenomic study of Statins in the Elderly at risk for cardiovascular disease (PHASE) |
| Citation |
Estrada Gil, K. (2012, June). Dissection of the Complex Genetic Architecture of Human Stature and Osteoporosis. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/32475
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| Additional Files | |
|---|---|
| stellingen Estrada Gil.pdf , 624kb | |
| 3536_Estrada Gil, Jesus Karol.jpg Cover Image , 77kb | |
