Osteoporosis is a common complex disease mostly characterized by decreased bone mineral density (BMD). In this thesis we show that hundreds of variants affect adult height and it is the same case for many other complex traits such as bone mineral density. We have applied the novel hypothesis-free approach of Genome-wide Association Study (GWAS) to identify those loci harboring at least one variant affecting these osteoporosis-related traits.

Additional Metadata
Keywords bone, fracture, genetics, height, osteoporosis, stature
Promotor A.G. Uitterlinden (André)
Publisher Erasmus University Rotterdam
ISBN 978-94-6169-246-7
Persistent URL hdl.handle.net/1765/32475
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/201865 - GENETIC FACTORS FOR OSTEOPOROSIS (GEFOS), This work was funded by the European Commission 7th Framework Programme; grant id fp7/223004 - A PHArmacogenomic study of Statins in the Elderly at risk for cardiovascular disease (PHASE)
Citation
Estrada Gil, K. (2012, June). Dissection of the Complex Genetic Architecture of Human Stature and Osteoporosis. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/32475