Osteoporosis is a common complex disease mostly characterized by decreased bone mineral density (BMD). In this thesis we show that hundreds of variants affect adult height and it is the same case for many other complex traits such as bone mineral density. We have applied the novel hypothesis-free approach of Genome-wide Association Study (GWAS) to identify those loci harboring at least one variant affecting these osteoporosis-related traits.

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A.G. Uitterlinden (André)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Estrada Gil, K. (2012, June). Dissection of the Complex Genetic Architecture of Human Stature and Osteoporosis. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/32475