Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

Ageing, Calcium, Supplementation, Vitamin D, Vitamin D receptor, Vitamin D resistance
dx.doi.org/10.1017/S0007114509338842, hdl.handle.net/1765/32728
British Journal of Nutrition
Erasmus MC: University Medical Center Rotterdam

Oudshoorn, C, van der Cammen, T.J.M, Mcmurdo, M.E.T, van Leeuwen, J.P.T.M, & Colin, E.M. (2009). Ageing and vitamin D deficiency: Effects on calcium homeostasis and considerations for vitamin D supplementation. British Journal of Nutrition (Vol. 101, pp. 1597–1606). doi:10.1017/S0007114509338842