We demonstrate a method to estimate the concentrations of water and lipid in scattering media such as biological tissues with diffuse optical spectra acquired over the range of 900 to 1600 nm. Estimations were performed by fitting the spectra to a model of light propagation in scattering media derived from diffusion theory. To validate the method, spectra were acquired from tissue phantoms consisting of lipid and water emulsions and swine tissues ex vivo with a two-fiber probe.

Lipid, Near-infrared spectroscopy, Tissue composition, Water
dx.doi.org/10.1117/1.3454392, hdl.handle.net/1765/33154
Journal of Biomedical Optics
Erasmus MC: University Medical Center Rotterdam

Nachabé, R, Hendriks, B.H.W, Desjardins, A.E, van der Voort, M, van der Mark, M.B, & Sterenborg, H.J.C.M. (2010). Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm. Journal of Biomedical Optics, 15(3). doi:10.1117/1.3454392