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A.D.M.E. Osterhaus (Albert), J. Groen (Jan) and E. de Clercq

1987

Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2'-deoxy-2'-fluoro-ß-D-arabinofuranosyl)-5-iodouracil on seal herpesvirus (Phocid herpesvirus 1) infection in vitro.

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Publication

Antiviral Research , Volume 7 - Issue 4 p. 221- 226

From a selection of 25 antiviral compounds with specific anti-herpes activity or broad-spectrum antiviral properties, two compounds, namely (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil, appeared particularly effective in inhibiting the cytopathogenicity of seal herpesvirus (phocid herpesvirus 1).

Additional Metadata
Keywords *Organophosphorus Compounds, 0 (Antiviral Agents), 0 (Organophosphorus Compounds), 3083-77-0 (Arabinofuranosyluracil), 58-96-8 (Uridine), 69123-98-4 (fialuridine), 73-24-5 (Adenine), 92999-29-6 (9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine), Adenine/*analogs & derivatives/pharmacology, Animals, Antiviral Agents/*pharmacology, Arabinofuranosyluracil/*analogs & derivatives/pharmacology, Cells, Cultured, Herpesviridae/*drug effects, Seals/microbiology, Support, Non-U.S. Gov't, Uridine/*analogs & derivatives
Persistent URL doi.org/10.1016/0166-3542(87)90030-1, hdl.handle.net/1765/3318
Journal Antiviral Research
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Osterhaus, A., Groen, J., & de Clercq, E. (1987). Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2'-deoxy-2'-fluoro-ß-D-arabinofuranosyl)-5-iodouracil on seal herpesvirus (Phocid herpesvirus 1) infection in vitro. Antiviral Research, 7(4), 221–226. doi:10.1016/0166-3542(87)90030-1
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