Combined optical and acoustical detection of single microbubble dynamics
Journal of the Acoustical Society of America , Volume 130 - Issue 5 p. 3271- 3281
A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field.
|Journal of the Acoustical Society of America|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Sijl, J, Vos, H.J, Rozendal, T, de Jong, N, Lohse, D, & Versluis, M. (2011). Combined optical and acoustical detection of single microbubble dynamics. Journal of the Acoustical Society of America, 130(5), 3271–3281. doi:10.1121/1.3626155