Pre-eclampsia (P-EC) poses an increased risk for fetal and maternal morbidity and sometimes even mortality. Several risk factors have been identified, among which an important extensively studied group is formed by the early recognizable genetic factors resulting in thrombophilia. The discussion is ongoing whether the associations found for thrombophilia are true and clinically relevant. In this review, we address the association between P-EC and thrombophilia, its concerns, and the necessity of screening after a pregnancy complicated by hypertension. © Copyright

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Keywords Thrombophilia, genetic variation, polymorphism, pre-eclampsia
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Journal Seminars in Thrombosis and Hemostasis
de Maat, M.P.M, & de Groot, C.J.M. (2011). Thrombophilia and pre-eclampsia. Seminars in Thrombosis and Hemostasis, 37(2), 106–110. doi:10.1055/s-0030-1270335