Hepatic haemangioendothelioma is a rare vascular tumour in infants and may be associated with a unique form of thyroid function abnormalities. Hepatic haemangioendotheliomata is capable of producing an excess of the thyroid hormone inactivating enzyme, type 3 iodothyronine deiodinase. The increased enzyme activity leads to rapid degradation of thyroid hormones, resulting in frank hypothyroidism. We report a case of a three-month-old neonate with multiple hepatic haemangioendotheliomata and associated hypothyroidism. The patient required increasing doses of thyroid hormone.

doi.org/10.1258/acb.2010.010170, hdl.handle.net/1765/33507
Annals of Clinical Biochemistry
Erasmus MC: University Medical Center Rotterdam

Jassam, N., Visser, T., Brisco, T., Bathia, D., McClean, P., & Barth, J. (2011). Consumptive hypothyroidism: A case report and review of the literature. Annals of Clinical Biochemistry, 48(2), 186–189. doi:10.1258/acb.2010.010170