The primary Moraxella catarrhalis-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age.Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag385-863, MID764-913, MID962-1200, UspA1557-704and UspA2165-318in cord blood compared to 6 months of age (P≤0.001). This was a most likely a consequence of maternal transmission of antigen-specific IgG to newborn babies, possibly indicating a future role for these 3 surface antigens in the development of an effective humoral immune response to M. catarrhalis. Finally, at 2 years of age, the levels of antigen-specific IgG still remained far below that obtained from cord blood samples, indicating that the immune response to M. catarrhalis has not matured at 2 years of age.We provide evidence that a humoral antibody response to OMPs UspA1, UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events.

Additional Metadata
Keywords Children, Colonization, Immune response, Moraxella catarrhalis, Surface antigens, Vaccine
Persistent URL,
Journal Vaccine
Verhaegh, S.J.C, de Vogel, C.P, Riesbeck, K, Lafontaine, E.R, Murphy, T.F, Verbrugh, H.A, … Hays, J.P. (2011). Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants. Vaccine, 29(34), 5603–5610. doi:10.1016/j.vaccine.2011.06.019