Aim: To establish to what extent somatic causes can be found in children referred to secondary care with recurrent abdominal pain. Methods: For 2 years, all consecutive patients (age 4-16 years) fulfilling Apley criteria, referred to secondary care, were included. After a diagnostic work-up, stepwise therapeutic interventions were performed. A diagnosis was considered to be the cause of the pain when the patient became pain free following therapeutic intervention and remained so for at least 6 months. Results: Two hundred and twenty children (128 F, 92 M; mean age 8.8 years) were enrolled, of which 20 were lost to follow-up. Spontaneous recovery was seen in 54 patients, (occult) constipation in 92 patients (of whom 18 also had a somatic cause), gastrointestinal infections in 40, food allergy in five, miscellaneous disorders in seven and uncertain diagnosis in 13. In five patients, stress most likely caused the pain. A total of 198 patients became pain free and remained so during follow-up (mean 18, range 6-60 months). Conclusion: In 200 children with recurrent abdominal pain, somatic causes were found in 26%. Laxative therapy was successful in 46%, resulting in nearly all patients with functional abdominal pain to become pain free. Eventually, 99% became pain free using a therapeutic intervention protocol. © 2011 The Author(s)/Acta Pædiatrica

Child, Constipation, Food allergy, Gastrointestinal infections, Recurrent abdominal pain,
Acta Paediatrica: promoting child health
Erasmus MC: University Medical Center Rotterdam

Gijsbers, C.F.M, Kneepkens, C.M.F, Schweizer, J.J, Benninga, M.A, & Büller, H.A. (2011). Recurrent abdominal pain in 200 children: Somatic causes and diagnostic criteria. Acta Paediatrica: promoting child health, 100(11). doi:10.1111/j.1651-2227.2011.02351.x